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Marconi C et al

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One important context point the headline numbers miss: in STEP-1, while absolute lean mass dropped, lean body mass *as a proportion of total body mass* actually rose by roughly 3 percentage points

Although our findings suggested notable variability in discontinuation rates between the IBS subtypes, the smaller subgroup numbers limited our ability to precisely attribute discontinuation to particular GI AEs, or to distinguish their prevalence among IBS subtypes